Publications

Research outputs from The Madsen Lab

We are committed to open access publishing. Preprint versions of all articles are available on bioRxiv where possible. For a full list of Dr. Madsen's publications, see her Google Scholar profile.

Selected Publications

PI3K inhibitor-free differentiation and maturation of human iPSC-derived arterial- and venous-like endothelial cells
Mruk O, Madsen RR
bioRxiv (2026)

Preprint Preprint
Oncogenic PIK3CA corrupts growth factor signalling specificity
Madsen RR, Le Marois A, Mruk O, Voliotis M, Yin S, Sufi J, Qin X, Zhao SJ, Gorczynska J, Morelli D, Davidson L, Sahai E, Korolchuk VI, Tape CJ, Vanhaesebroeck B
Molecular Systems Biology (2024)

We develop a single-cell framework for quantifying PI3K signalling and show that oncogenic PIK3CA corrupts the specificity of growth factor signal encoding.

Published Published version
Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation
Erickson EC, You I, Perry G, Dugourd A, Donovan K, Ros S, Moss J, Ziegler R, Williamson S, Crafter C, Johannes J, Barry S, Fischer E, Gray N, Madsen RR, Toker A
Science Signaling (2024)

Published Published version
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Gong GQ, Allsop B, Masson GR, Roberton V, Bilanges B, Askwith T, Oxenford S, Madsen RR, Conduit SE, Fitzek M, Collier M, Chan E, Feierberg I, Madin A, Morelli D, Bhamra A, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Whitehead MA, Davidson SM, Yellow DM, Perisic O, Hooper A, Patel C, Bunney TD, Katan D, Smith D, Phillips J, Williams RL, Angell R, Vanhaesebroeck B
Nature (2023)

Published Published version
Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signalling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype
Madsen RR, Erickson EC, Rueda OM, Robin X, Caldas C, Toker A, Semple RK, Vanhaesebroeck B
PLOS Genetics (2021)

Published Published version
NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CA-H1047R homozygosity in pluripotent stem cells
Madsen RR, Longden J, Knox RG, Macleod K, Xavier R, Völlmy F, Moniz L, Carragher N, Vanhaesebroeck B, Linding R, Semple RK
Disease Models & Mechanisms (2021)

Published Published version
Genetic activation of PIK3CA in human pluripotent stem cells reveals allele dose-dependent developmental effects
Madsen RR, Knox RG, Pearce W, Lopez S, Mahler-Araujo B, McGranahan N, Vanhaesebroeck B, Semple RK
PNAS (2019)

PNAS 2019, 116, pp. 8380–8389.

Published
Cancer signaling beyond the genes
Levchenko A. and Madsen RR
Current Opinion in Cell Biology (2026)

Current Opinion in Cell Biology 100 (June 2026): 102643

Published Published version
PI3K signalling through a biochemical systems lens
Madsen RR, Toker A
Journal of Biological Chemistry (2023)

JBC 2023, 299(10), 105224.

Published
Cracking the context-specific PI3K signalling code
Madsen RR, Vanhaesebroeck B
Science Signaling (2020)

Science Signaling 2020, Jan 7; 13, eaay2940.

Published
Cancer-associated PIK3CA mutations in overgrowth disorders
Madsen RR, Vanhaesebroeck B, Semple RK
Trends in Molecular Medicine (2018)

Trends Mol Med 2018, 24(10), pp. 856–870.

Published

All Publications

Mosaic hotspot PIK3CA mutations cause non-cell-autonomous vascular overgrowth and pan-lineage dysregulation at disease onset
Brunsdon H, Wang N, Raredon MSB, Madsen RR, Semple RK, Patton EE
bioRxiv (2025)
Preprint Preprint
Non-equilibrium strategies for ligand specificity in signaling networks
Goetz A, Barrios J, Madsen RR, Dixit P
eLife (2025)
Published Published version
SIGNAL-seq: Multimodal single-cell inter- and intra-cellular signalling analysis
Opzoomer JW, O'Sullivan R, Sufi J, Madsen RR, Qin X, Basiarz E, Tape CJ
bioRxiv (2024)
Preprint Preprint
Cholesterol biosynthesis inhibition synergizes with AKT inhibitors in triple-negative breast cancer
Hillis AL, Martin TD, Manchester HE, Hogstrom JM, Zhang N, Lecky E, Kozlova N, Persky NS, Root DE, Brown M, Cichowski K, Elledge SJ, Muranen T, Fruman DA, Barry ST, Clohessy JG, Madsen RR, Toker A
Cancer Research (2024)
Published Published version
mTORC1 activity is supported by spatial association with focal adhesions
Rabanal-Ruiz Y, Byron A, Wirth A, Madsen RR, Sedlackova L, Hewitt G, Nelson G, Stingele J, Wills JC, Zhang T, Zeug A, Fässler R, Vanhaesebroeck B, Maddocks ODK, Ponimaskin E, Carroll B, Korolchuk V
Journal of Cell Biology (2021)
Published Published version
Luminescent peptide tagging enables efficient screening for CRISPR-mediated knock-in in human induced pluripotent stem cells
Madsen RR, Semple RK
Wellcome Open Research (2019)
Published
Epigenetic regulation of vascular smooth muscle cells by histone H3 lysine 9 dimethylation attenuates target gene-induction by inflammatory signalling
Harman JL, Dobnikar L, Chappell J, Stokell BG, Dalby A, Foote K, Finigan A, Freire-Pritchett P, Taylor AL, Worssam MD, Madsen RR, Loche E, Uryga A, Bennett MR, Jorgensen HF
Arteriosclerosis, Thrombosis, and Vascular Biology (2019)
Published
Coenzyme Q10 prevents insulin signaling dysregulation and inflammation prior to development of insulin resistance in male offspring of a rat model of poor maternal nutrition and accelerated postnatal growth
Tarry-Adkins JL, Fernandez-Twinn DS, Madsen RR, Chen JH, Carpenter A, Hargreaves IP, McConnell JM, Ozanne SE
Endocrinology (2015)
Published
mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node
Mantoan Ritter L, Annear NMP, Baple EL, Ben-Chaabane LY, Bodi I, Brosson L, Cadwgan JE, Coslett B, Crosby AH, Davies DM, Daykin N, Dedeurwaerdere S, Dühring Fenger C, Dunlop EA, Elmslie FV, Girodengo M, Hambleton S, Jansen AC, Johnson SR, Kearley KC, Kingswood JC, Laaniste L, Lachlan K, Latchford A, Madsen RR, Mansour S, Mihaylov SR, Muhammed L, Oliver C, Pepper T, Rawlins LE, Schim van der Loeff I, Siddiqui A, Takhar P, Tatton-Brown K, Tee AR, Tibarewal P, Tye C, Ultanir SK, Vanhaesebroeck B, Zare B, Pal DK, Bateman JM
Orphanet Journal of Rare Diseases (2025)
Published
PIK3CA-related overgrowth: silver bullets from the cancer arsenal?
Madsen RR, Semple RK
Trends in Molecular Medicine (2022)
Published
Precision targeting of mutant PI3Kα in cancer by selective degradation
Vanhaesebroeck B, Burke JE, Madsen RR
Cancer Discovery (2022)
Published
PI3K in stemness regulation: from development to cancer
Madsen RR
Biochemical Society Transactions (2020)
Published
Perspective: potential impact and therapeutic implications of oncogenic PI3K activation on chromosomal instability
Vanhaesebroeck B, Bilanges B, Madsen RR, Dale KL, Lau E, Vladimirou E
Biomolecules (2019)
Published
Principles of PI3K biology and its role in lymphoma
Madsen RR
Targeting Oncogenic Drivers and Signaling Pathways in Hematologic Malignancies: From Concept to Practice (Wiley-Blackwell) (2023)
Published

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